Temporary Upregulation of Nrf2 by Naringenin Alleviates Oxidative Damage in the Retina and ARPE-19 Cells

Figure 6

Overexpression of Nrf2 induced by NaIO₃ promoted the death of ARPE-19 cells. (a) Protein expressions of Nrf2 and HO-1 in ARPE-19 cells stimulated by NaIO₃ for 24 h. (b) Representative fluorescence images of ROS and carbonyl protein in ARPE-19 cells cotreated with 10 mM NaIO₃ and ML385 for 24 h. (c) The viability of cells cotreated with 10 mM NaIO₃ and ML385 for 24 h and 48 h. (d) The viability of cells cotreated with 8 mM NaIO₃ and ML385 for 48 h. (e) The viability of cells cotreated with 10 mM NaIO₃, ML385, and/or NAR for 24 h. Data were expressed as the , . vs. normal group, ^## vs. model group, and ^AA vs. corresponding NAR group (Tukey’s test).

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