OC-STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis

Figure 3

Overexpression of OC-STAMP promotes ER stress and cellular senescence in MLE-12 cells. (a) Levels of p-PERK, p-EIF 2α, p-NF-κB, and p-IRE 1α in MLE-12 cells, measured by Western blotting. Data are presented as the ; per group; (b) SA-β-gal staining; (c) coexpression of PCNA and p21 in MLE-12 cells. ; (d) levels of p-ATM, p-ATR, p-p53, p21, and p16 in MLE-12 cells measured by Western blotting. Data are presented as the ; per group.

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