Research Article

CaMK II Inhibition Attenuates ROS Dependent Necroptosis in Acinar Cells and Protects against Acute Pancreatitis in Mice

Figure 3

KN93 decreased macrophages and neutrophils in pancreatic tissues of the AP mouse model. (a–d) Leukocytes from pancreas and spleen were isolated for staining and flow cytometry analysis. Representative flow cytometry gating of pancreatic macrophages (a) and neutrophils (c) is shown. (b, d) The percentages of CD11b +F4/80+ macrophages and CD11b+Gr-1+ neutrophils from pancreas and spleen are shown () as scatter plots. each group. (e) Representative immunohistochemistry images for myeloperoxidase (MPO) and CD68 in the pancreas. Scar μM. (f) The frequencies of MPO positive rate and CD68 positive rate in pancreas. each group. and . H represents high-dose KN93 (20 mg/kg).
(a)
(b)
(c)
(d)
(e)
(f)