CaMK II Inhibition Attenuates ROS Dependent Necroptosis in Acinar Cells and Protects against Acute Pancreatitis in Mice

<div>KN93 reduced acinar cell necroptosis and decreased the production of ROS in acinar cells in the AP mice. (a) Representative immunohistochemistry images for RIP3 and p-MLKL expression in the pancreas. 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(b) Representative immunofluorescence image of DHE in magnification 200x. 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(c) Densitometric analysis of DHE fluorescence. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: CaMK II Inhibition Attenuates ROS Dependent Necroptosis in Acinar Cells and Protects against Acute Pancreatitis in Mice 