Zinc Regulates Glucose Metabolism of the Spinal Cord and Neurons and Promotes Functional Recovery after Spinal Cord Injury through the AMPK Signaling Pathway

Figure 8

The scheme of zinc regulating neuronal glucose metabolism after SCI. After SCI, neuronal glucose transport, mitochondrial biogenesis, and mitochondrial membrane potential of the neurons were decreased, with ROS accumulating and oxidative stress increasing (black arrow). Through the AMPK pathway, zinc strengthened neuronal glucose transport, promoted mitochondrial biogenesis, increased mitochondrial membrane potential, and reduced oxidative stress after SCI (blue arrow). Compound C suppressed the effect of zinc (red arrow).