Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey

Table 2

Univariate linear regression for association between total bilirubin concentrations and mean telomere length.

	Number of subjects	Mean telomere length [β (95% CI)]	value
Age, years
<40	2805 (35.88)	Ref
40- <50	1337 (17.10)	-0.09 (-0.10, -0.07)	<0.001
50- <60	1008 (12.89)	-0.15 (-0.17, -0.13)	<0.001
≥60	2668 (34.13)	-0.25 (-0.26, -0.23)	<0.001
Sex, %
Male	3767 (48.18)	Ref
Female	4051 (51.82)	0.04 (0.02, 0.05)	<0.001
Race, %
Non-Hispanic White	3960 (50.65)	Ref
Non-Hispanic Black	1331 (17.02)	0.07 (0.05, 0.09)	<0.001
Mexican American	1874 (23.97)	-0.01 (-0.03, 0.00)	0.131
Other Hispanic	417 (5.33)	0.06 (0.03, 0.08)	<0.001
Other	236 (3.02)	0.04 (-0.00, 0.07)	0.055
Education, %
< High school	2635 (33.76)	Ref
High school	1812 (23.21)	0.05 (0.03, 0.07)	<0.001
>High school	3359 (43.03)	0.06 (0.05, 0.08)	<0.001
Body mass index, kg/m^2
<18.5	2289 (30.24)	0.03 (-0.02, 0.09)	0.229
18.5- <25	110 (1.45)	Ref
25- <30	2752 (36.36)	-0.04 (-0.05, -0.02)	<0.001
≥30	2418 (31.95)	-0.04 (-0.06, -0.02)	<0.001
Smoke status, %
None	4010 (51.39)	Ref
Past	2099 (26.90)	-0.07 (-0.09, -0.06)	<0.001
Current	1694 (21.71)	0.01 (-0.01, 0.03)	0.241
Physical activity, MET/week
No aerobic activity	2052 (28.18)	Ref
Low activity	1977 (27.15)	0.04 (0.02, 0.06)	<0.001
Moderate activity	1237 (16.98)	0.04 (0.02, 0.06)	<0.001
High activity	2017 (27.69)	0.05 (0.04, 0.07)	<0.001
Energy intake
Q1	1697 (22.60)	Ref
Q2	1787 (23.80)	0.02 (-0.00, 0.03)	0.060
Q3	1833 (24.41)	0.04 (0.02, 0.06)	<0.001
Q4	2191 (29.18)	0.07 (0.06, 0.09)	<0.001
Alcohol use, %
No	5556 (74.00)	Ref
Yes	1952 (26.00)	0.02 (0.00, 0.03)	0.015
Diabetes, %
No	6878 (88.77)	Ref
Yes	870 (11.23)	-0.08 (-0.10, -0.07)	<0.001
Hypertension, %
No	5384 (69.23)	Ref
Yes	2393 (30.77)	-0.08 (-0.09, -0.07)	<0.001
C-reactive protein
Q1	1056 (13.51)	0
Q2	3019 (38.62)	-0.08 (-0.10, -0.06)	<0.001
Q3	3743 (47.88)	-0.11 (-0.13, -0.09)	<0.001