Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey
Table 5
The association between total bilirubin concentrations and mean telomere length in different subgroups.
Total bilirubin, mg/dL
Q1 ()
Q2 ()
Q3 ()
Q4 ()
Q5 ()
β (95% CI)
value
β (95% CI)
value
β (95% CI)
value
β (95% CI)
value
Age, year
<45
Ref
0.04 (0.00, 0.07)
0.026
0.05 (0.02, 0.08)
<0.001
0.04 (0.01, 0.07)
0.006
0.04 (0.01, 0.07)
0.013
45-<60
Ref
0.06 (0.01, 0.10)
0.008
0.08 (0.04, 0.11)
<0.001
0.05 (0.01, 0.08)
0.011
0.05 (0.01, 0.09)
0.007
≥60
Ref
-0.02 (-0.05, 0.00)
0.103
0.00 (-0.02, 0.03)
0.756
-0.00 (-0.03, 0.02)
0.780
-0.01 (-0.03, 0.02)
0.691
Body mass index, kg/m2
<18.5
Ref
0.02 (-0.20, 0.24)
0.885
0.17 (-0.02, 0.37)
0.086
-0.04 (-0.23, 0.15)
0.696
0.01 (-0.19, 0.21)
0.910
18.5- <25
Ref
0.01 (-0.04, 0.05)
0.741
0.06 (0.02, 0.10)
0.003
0.04 (0.00, 0.08)
0.032
0.04 (-0.00, 0.08)
0.078
25- <30
Ref
0.03 (0.00, 0.06)
0.025
0.03 (0.01, 0.06)
0.018
0.04 (0.01, 0.07)
0.007
0.03 (-0.00, 0.06)
0.075
≥30
Ref
0.01 (-0.01, 0.04)
0.337
0.04 (0.02, 0.07)
0.002
0.03 (-0.00, 0.06)
0.064
0.04 (0.01, 0.08)
0.012
Smoke status, %
None
Ref
0.02 (-0.00, 0.05)
0.097
0.04 (0.02, 0.07)
0.001
0.03 (0.01, 0.06)
0.012
0.02 (-0.01, 0.05)
0.127
Past
Ref
0.02 (-0.01, 0.06)
0.160
0.04 (0.01, 0.07)
0.017
0.05 (0.02, 0.08)
0.003
0.05 (0.02, 0.08)
0.003
Current
Ref
0.02 (-0.02, 0.05)
0.378
0.07 (0.03, 0.10)
<0.001
0.03 (-0.01, 0.07)
0.098
0.06 (0.02, 0.10)
0.005
Energy intake, kcal
Q1
Ref
0.01 (-0.03, 0.04)
0.687
0.05 (0.01, 0.08)
0.005
0.03 (-0.01, 0.06)
0.155
0.04 (0.00, 0.08)
0.050
Q2
Ref
0.03 (-0.01, 0.06)
0.159
0.03 (-0.00, 0.06)
0.074
0.01 (-0.02, 0.04)
0.546
0.02 (-0.02, 0.06)
0.283
Q3
Ref
0.04 (0.01, 0.08)
0.020
0.06 (0.03, 0.10)
<0.001
0.04 (0.01, 0.08)
0.011
0.03 (-0.00, 0.07)
0.054
Q4
Ref
0.01 (-0.02, 0.05)
0.536
0.05 (0.01, 0.08)
0.005
0.04 (0.01, 0.08)
0.009
0.05 (0.01, 0.08)
0.008
Alcohol use, %
No
Ref
0.02 (0.00, 0.04)
0.027
0.05 (0.03, 0.07)
<0.001
0.03 (0.01, 0.05)
0.002
0.04 (0.02, 0.06)
<0.001
Yes
Ref
0.01 (-0.02, 0.05)
0.455
0.04 (0.00, 0.07)
0.039
0.03 (-0.00, 0.07)
0.062
0.03 (-0.01, 0.06)
0.156
Physical activity, MET/week
No aerobic activity
Ref
0.02 (-0.02, 0.06)
0.329
0.04 (0.00, 0.08)
0.032
0.04 (0.00, 0.08)
0.047
0.04 (-0.01, 0.08)
0.094
Low activity
Ref
0.04 (0.01, 0.08)
0.013
0.06 (0.03, 0.09)
<0.001
0.04 (0.01, 0.08)
0.008
0.04 (0.01, 0.08)
0.017
Moderate activity
Ref
-0.00 (-0.05, 0.04)
0.992
0.07 (0.03, 0.11)
0.001
0.04 (0.00, 0.08)
0.049
0.03 (-0.02, 0.07)
0.221
High activity
Ref
0.03 (-0.01, 0.07)
0.092
0.05 (0.02, 0.08)
0.005
0.03 (-0.00, 0.07)
0.076
0.04 (0.00, 0.08)
0.039
Diabetes, %
No
Ref
0.03 (0.01, 0.05)
0.012
0.05 (0.03, 0.07)
<0.001
0.04 (0.02, 0.06)
<0.001
0.03 (0.01, 0.05)
0.001
Yes
Ref
-0.01 (-0.05, 0.04)
0.782
0.02 (-0.02, 0.07)
0.294
0.03 (-0.02, 0.08)
0.289
0.05 (-0.00, 0.10)
0.065
Hypertension, %
No
Ref
0.02 (-0.00, 0.05)
0.063
0.05 (0.02, 0.07)
<0.001
0.05 (0.03, 0.07)
<0.001
0.04 (0.02, 0.06)
0.001
Yes
Ref
0.02 (-0.01, 0.05)
0.297
0.05 (0.02, 0.07)
0.001
0.01 (-0.02, 0.04)
0.567
0.03 (0.00, 0.06)
0.043
C-reactive protein
Q1
Ref
0.03 (-0.01, 0.08)
0.144
0.06 (0.01, 0.10)
0.008
0.04 (-0.00, 0.08)
0.074
0.05 (0.01, 0.09)
0.024
Q2
Ref
0.02 (-0.01, 0.05) 0.1843
0.184
0.04 (0.02, 0.07)
0.002
0.05 (0.02, 0.07)
<0.001
0.02 (-0.01, 0.05)
0.133
Q3
Ref
0.01 (-0.01, 0.04)
0.326
0.04 (0.02, 0.07)
<0.001
0.03 (-0.00, 0.05)
0.059
0.05 (0.01, 0.08)
0.007
Adjusted model adjust for age (continuous), race (non-Hispanic white, black, Mexican American, other Hispanic, other race/ethnicity or missing), education (less than high school, high school, more than high school, or missing), body mass index (<18.5, 18.5- <25, 25- <30, ≥30, or missing), smoke status (none, past, current, or missing), alcohol (yes, no, or missing), physical activity (no aerobic activity, low activity, moderate activity, high activity, or missing), energy intake (Q1-Q4), diabetes (yes, no, or missing), hypertension (yes, no, or missing), and C-reactive protein (Q1-Q3).
