Downregulation of CYP39A1 Serves as a Novel Biomarker in Hepatocellular Carcinoma with Worse Clinical Outcome

Figure 2

Differential mRNA expression of CYP39A1 between HCC and noncancerous liver tissues. (a) The GSE14520 dataset with two cohorts showed that CYP39A1 mRNA expression was decreased in HCC tissues compared with adjacent noncancerous liver tissues (, paired -test). (b) The GSE45267 dataset showed that CYP39A1 mRNA expression was decreased in HCC tissues compared with unpaired noncancerous liver tissues (, unpaired -test). (c) Sixty paired HCC biopsies from an unselected patient population with all tumor stages from GSE64041 indicated that CYP39A1 mRNA was lower in HCC tissues than in adjacent noncancerous liver tissues (, paired -test). (d) Relative expression value of CYP39A1 in HCC and noncancerous liver tissues in the three GSE datasets. (e) CYP39A1 mRNA expression was downregulated in HCC tissues in the TCGA dataset analysis. (f) CYP39A1 mRNA expression in 14 fresh-frozen liver tissues. (C: cancer tissue; N: noncancerous tissue).

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