Melatonin Exerts Cardioprotective Effects by Inhibiting NLRP3 Inflammasome-Induced Pyroptosis in Mice following Myocardial Infarction

Figure 1

Cardiac injury was reversed by melatonin treatment in MI mice. (a) Diagram of the experimental protocol. (b) Representative LV sections stained with TTC and statistical analysis of infarct area data in mice. The infarct region is labeled in white. vs. sham, ^# vs. MI. . (c) Representative echocardiography images from different groups. (d, e) Statistical analysis of echocardiographic EF% and FS% data in MI mice treated with or without melatonin. vs. sham, ^# vs. MI. . (f) Representative images of H&E staining of the mouse heart. Scale bar, 20 μm. MI: myocardial infarction; MLT: melatonin.

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