Total Flavonoids of Crocus sativus Petals Release tert-Butyl Hydroperoxide-Induced Oxidative Stress in BRL-3A Cells

Figure 2

Cytotoxicity and cytoprotective effects of total flavonoid extract from saffron petals (TFESP). BRL-3A cells treated with various concentrations of TFESP (50–300 μg/mL) for 24 h and pretreated for 24 h with indicated TFESP concentrations (low concentration, 25 μg/mL; middle concentration, 50 μg/mL; high concentration, 100 μg/mL) before treatment with 100 μM t-BHP. Statistical significance: ^#, ^##, ^###, and ^####, contrasted to the control group; , , , and , contrasted to the t-BHP-treated group.