Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells

Figure 6

BCT-100 suppressed tumor growth in vivo. (a) Relative tumor volume and (b) median survival of mice in the mock-treated and BCT-100-treated groups (20 mg/kg and 60 mg/kg) recorded in different time points ( per group). (c) Expression of PEG, LC3B, C-PARP, and Survivin assessed by Western blot. Serum (d) and intratumoral (e) arginine levels in mice were detected by L-arginine kit. (f) Immunofluorescence staining of Ki67 in mock-treated and BCT-100-treated mice. Bar, 30 μm. All data are presented as the of three independent experiments., , and , as evaluated by Student’s -test.

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