ALKBH5 Exacerbates Aortic Dissection by Promoting Inflammatory Response and Apoptosis of Aortic Smooth Muscle Cells via Regulating lnc-TMPO-AS1/EZH2/IRAK4 Signals in an m6A Modification Manner

<div>ALKBH5 is upregulated in AD tissues and HASMCs treated with AngII. (a) The expression levels of multiple key genes related to m6A modification were measured in 40 pairs of the AD and normal arterial tissues. (b) The results of western blot also revealed the low expression of KIAA1429 and the high expression of ALKBH5 in aortic tissues from AD patients. (c, d) The results of western blot also revealed the low expression of KIAA1429 and the high expression of ALKBH5 in aortic tissues from AD mice compared with normal mice. (e, f) The results of western blot also revealed the low expression of KIAA1429 and the high expression of ALKBH5 in HASMCs treated with AngII. 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Oxidative Medicine and Cellular Longevity

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Figure 1

Figure 1: ALKBH5 Exacerbates Aortic Dissection by Promoting Inflammatory Response and Apoptosis of Aortic Smooth Muscle Cells via Regulating lnc-TMPO-AS1/EZH2/IRAK4 Signals in an m6A Modification Manner 

Figure 1 | ALKBH5 Exacerbates Aortic Dissection by Promoting Inflammatory Response and Apoptosis of Aortic Smooth Muscle Cells via Regulating lnc-TMPO-AS1/EZH2/IRAK4 Signals in an m6A Modification Manner 