Rosiglitazone Suppresses Renal Crystal Deposition by Ameliorating Tubular Injury Resulted from Oxidative Stress and Inflammatory Response via Promoting the Nrf2/HO-1 Pathway and Shifting Macrophage Polarization

<div>ROSI decreased renal macrophage recruitment and M1Mp polarization and promoted renal M2Mp polarization in the mouse model. (a) Immunohistochemical distribution of genetic expression of PPAR<i>γ</i>, macrophage-related molecules, and proinflammatory cytokines (arrows). 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(c) Flow cytometric detection of Mps in kidney tissues. (d) The proportion of M1Mps and M2Mps in kidney tissues. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Rosiglitazone Suppresses Renal Crystal Deposition by Ameliorating Tubular Injury Resulted from Oxidative Stress and Inflammatory Response via Promoting the Nrf2/HO-1 Pathway and Shifting Macrophage Polarization 

Figure 5 | Rosiglitazone Suppresses Renal Crystal Deposition by Ameliorating Tubular Injury Resulted from Oxidative Stress and Inflammatory Response via Promoting the Nrf2/HO-1 Pathway and Shifting Macrophage Polarization 