Circulating Metabolomic Analysis following Cecal Ligation and Puncture in Young and Aged Mice Reveals Age-Associated Temporal Shifts in Nicotinamide and Histidine/Histamine Metabolic Pathways

Figure 1

Summary of the experimental protocol and establishment of aged mouse frailty. (a) Graphical representation of the experimental design, including the sampling strategies and the various experimental groups included for analysis. (b) Description of the intraprocedural survival, demonstrating statistically significantly enhanced mortality for the aged animals in the protocol compared to the young. Alanine aminotransferase (c) and aspartate aminotransferase (d) levels in the plasma of animals at various timepoints, demonstrating increased levels of liver damage in the aged animals throughout the protocol when compared to the young animals.

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