Circulating Metabolomic Analysis following Cecal Ligation and Puncture in Young and Aged Mice Reveals Age-Associated Temporal Shifts in Nicotinamide and Histidine/Histamine Metabolic Pathways

Figure 3

Identification of the metabolic pathways that drive the response to CLP in young animals. PCA plots of the young sham (a) and CLP (b) metabolomes. Sham-treated animals demonstrated a return to baseline over time, while CLP-treated animals did not. (c) Profile of the top 100 metabolites that differentiate between CLP and sham interventions in young mice over time. (d) Pathway analysis comparing enrichment of the top 100 metabolites compared to the 566 metabolites originally contained in the dataset. (e) Heatmap analysis demonstrating group average values of the top 100 metabolites at all CLP and sham surgical timepoints in young animals, illustrating broad differences in metabolomic responses following CLP compared to sham intervention.

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