Circulating Metabolomic Analysis following Cecal Ligation and Puncture in Young and Aged Mice Reveals Age-Associated Temporal Shifts in Nicotinamide and Histidine/Histamine Metabolic Pathways

Figure 6

Detailed view of the nicotinate-nicotinamide metabolic pathway. Schematic representation of the nicotinate-nicotinamide pathway organized according to KEGG pathway diagrams, with individual values plotted for each of the four experimental groups (young sham, young CLP, aged sham, and aged CLP). As previously, data was graphed for all available metabolites in the pathway, and undetected metabolites were left as labeled boxes. Statistical testing was accomplished using two-way ANOVA, and significance in this analysis was denoted in the right lower corner of each metabolite graph using G (group), T (timepoint), or I (interaction). Post hoc multiple comparisons testing was done to evaluate the differences between both aged CLP and aged sham as well as aged CLP and young CLP, as described in the methods.