Role of Human NADPH Quinone Oxidoreductase (NQO1) in Oxygen-Mediated Cellular Injury and Oxidative DNA Damage in Human Pulmonary Cells

<div>Hyperoxia decreased DNA adduct formation in <sup>32</sup>P-postlabeling experiments, and high cellular levels of NQO1 and CYP1A1 might attenuate such effect. (a) A typical result of a <sup>32</sup>P-postlabeling experiment showing chromatographic images labeled with AcA, GcA, CcA, and TcA. (b) Quantitation of the <sup>32</sup>P-postlabeling experiment. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Role of Human NADPH Quinone Oxidoreductase (NQO1) in Oxygen-Mediated Cellular Injury and Oxidative DNA Damage in Human Pulmonary Cells 