Protein Phosphatase 4 Promotes Hepatocyte Lipoapoptosis by Regulating RAC1/MLK3/JNK Pathway

Figure 7

Molecular mechanism by which PP4 participates in hepatocyte lipoapoptosis. Stimulation of PP4 by SFAs causes enhanced GTPase activity of RAC1 possibly by dephosphorylating RAC1, which subsequently activate MLK3/JNK pathway, which led to elevated expression of Bcl-2 proapoptotic family members and promoted hepatocyte lipoapoptosis.