SM22α Loss Contributes to Apoptosis of Vascular Smooth Muscle Cells via Macrophage-Derived circRasGEF1B

Figure 7

Mechanism of SM22α ameliorates macrophage-induced apoptosis in VSMCs. VSMCs missing SM22α activate macrophages in a VCAM-1-dependent manner and induce the self-apoptosis via circRasGEF1B-ZFP36-mediated Bcl-2 mRNA decay.