Artemisinin Reverses Glucocorticoid-Induced Injury in Bone Marrow-Derived Mesenchymal Stem Cells through Regulation of ERK1/2-CREB Signaling Pathway

Figure 2

Artemisinin attenuated the decrease of cell viability induced by DEXA. (a) BMSCs were pretreated with different concentrations of artemisinin (ART) or DMSO (1%, vehicle control, CTRL) for 1 h before incubation with 30 μM DEXA for another 24 h; the cell viability was detected by MTT assay (). (b) BMSCs were pretreated with artemisinin (ART, 1.0 μM) or DMSO (1%, vehicle control, CTRL) for 1 h before incubation with 30 μM DEXA for another 24 h; the cell viability was detected by FACS using PI staining (). (c) Quantification of (b) (). and were considered significantly different. CTRL: control; ART: artemisinin; DEXA: dexamethasone; ART + DEXA: treated with artemisinin followed by incubation with DEXA.

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