Artemisinin Reverses Glucocorticoid-Induced Injury in Bone Marrow-Derived Mesenchymal Stem Cells through Regulation of ERK1/2-CREB Signaling Pathway

Figure 9

Artemisinin stimulated ERK1/2, CREB phosphorylation, and BCL-2 production. (a) BMSCs were seeded on 6-well plates at a density of 1- cells/mL and treated with different concentrations of artemisinin for 1 h. The expression levels of P-ERK1/2, P-CREB, BCL-2, and Bax were assessed by Western blot analysis (). (b–d) Quantification of (a). (e) BMSCs were treated with different concentrations of artemisinin for 1 h, and the phosphorylation of CREB was detected my immunofluorescence (). , , and were considered significantly different in comparison to the control group (0 μM).

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