Stimulation of AMPK Prevents Diabetes-Induced Photoreceptor Cell Degeneration

Figure 5

Effect of AMPK on mitochondrial function in 661w cells after AGE treatment. The effect of AMPK on the expression of PGC1α (a), Nrf1 (b), Tfam (c), and SOD2 (d) and the DNA copy number (g) in 661w cells treated with AGEs was measured by qRT-PCR. (e, f) The effect of AMPK on the mitochondrial membrane potential in 661w cells after AGE treatment. (h) Effect of AMPK on mitochondrial morphology in 661w cells was observed by transmission electron microscopy. The data are expressed as the ( for each group). , , .

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