Antiepileptic Effects of Cicadae Periostracum on Mice and Its Antiapoptotic Effects in H₂O₂-Stimulated PC12 Cells via Regulation of PI3K/Akt/Nrf2 Signaling Pathways

Table 3

Antiepileptic effect of CPM on strychnine induced seizure in mice.

Treatment	Seizure latency (s)	Death latency (s)	Seizure rate (%)	Death rate (%)
Model			100	100
Positive			0	0
100 mg/kg			100	100
200 mg/kg			80	60
400 mg/kg			60	40

CPM: Cicadae Periostracum. Diazepam was used as a positive model. Mice were divided into five groups (): model group (mice were treated with normal saline, 20 mL/kg, p.o.), positive group (mice were treated with diazepam, 4 mg/kg, i.p.), and three tested CPM groups (mice were treated with CPM at the doses of 100, 200, and 400 mg/kg, p.o.). The chi-squared test was used to analyze significance of anticonvulsant effects against strychnine-induced seizures among groups (inhibition (%) and mortality (%)). All other data were presented as (), and statistical analyses were performed using the two-tailed Student’s test, and vs. model.