Aquaporin 9 Represents a Novel Target of Chronic Liver Injury That May Antagonize Its Progression by Reducing Lipotoxicity

Figure 5

Mechanistic screening of AQP9 involved in CLI by proteomics analysis. (a) KEGG enrichment analysis of differential proteins in the KO-CCl₄ and WT-CCl₄ groups. (b–e) Cluster analysis of different proteins related to lipid metabolism, inflammation, oxidative stress, and apoptosis in the KO-CCl₄ and WT-CCl₄ groups. Differentially significant expressed proteins were screened with the cutoff of a ratio fold-change of >1.20 or <0.83 and . Red: upregulation; blue: downregulation. .

(a)

(b)

(c)

(d)

(e)