[Retracted] ROS Signaling-Mediated Novel Biological Targets: Brf1 and RNA Pol III Genes

Figure 3

Schematic illustration of ROS-mediated deregulation of Brf1 and Pol III gene transcription. ROS causes deregulation of Brf1 expression and RNA Pol III gene transcription through various pathways, resulting in the alterations of cellular phenotypes, eventually cancer development.