Xinmailong Attenuates Doxorubicin-Induced Lysosomal Dysfunction and Oxidative Stress in H9c2 Cells via HO-1

Figure 1

XML alleviates the increased cell proliferation and SOD activity in DOX-induced H9c2 cells. (a, b) Cell proliferation was assessed by CCK-8. (c) Cell oxidative stress was reflected by SOD activity. H9c2 cells were treated with 0.25, 0.5, 1, 2, and 4 mg/mL XML alone for 24 h. H9c2 cells were treated with DOX for 24 h only or preincubated with 0.25, 0.5, and 1 mg/mL XML for 48 h. Data are representative of at least three independent experiments (). Statistical significance was assigned as and compared with control and ^# compared with DOX. values were determined using the independent one-way ANOVA and the Tukey-Kramer test. XML: Xinmailong treatment; DOX: doxorubicin; CCK8: Cell Counting Kit-8; SOD: superoxide dismutase.

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