Research Article

Early Perihematomal Edema Expansion: Definition, Significance, and Association with Outcomes after Intracerebral Hemorrhage

Table 1

Comparison of baseline demographic, clinical, and radiological characteristics between patients with and without favorable outcome.

VariablesPatients, no. (%)
Favorable outcome (, 61.8%)Poor outcome (, 38.2%) value

Demographic
Mean age, y (SD)58.6 (11.5)62.7 (12.4)0.011
Sex, male, (%)87 (60.4)61 (68.5)0.211
Medical history
Alcohol consumption, (%)57 (39.6)38 (42.7)0.638
Smoking, (%)61 (42.4)44 (49.4)0.291
Hypertension, (%)103 (71.5)71 (79.8)0.160
Diabetes mellitus, (%)14 (9.7)12 (13.5)0.376
Clinical features
Systolic blood pressure, mmHg (SD)167.5 (26.0)176.6 (35.0)0.035
Diastolic blood pressure, mmHg (SD)97.3 (14.5)101.2 (21.6)0.128
Admission GCS score, median (IQR)14 (13-15)10 (7-14)<0.001
Baseline ICH volume, mL (IQR)11.7 (7.1-16.4)18.7 (11.1-32.0)<0.001
Time from onset to CT, h(IQR)2.0 (1.0-4.0)2.0 (1.0-3.0)0.046
Admission PHE volume, mL (IQR)5.3 (2.6-8.3)7.5 (4.7-14.7)<0.001
Follow-up PHE volume, mL (IQR)7.8 (4.0-11.1)13.7 (7.0-25.1)<0.001
Absolute PHE increase, mL (IQR)1.5 (0.1-3.5)3.8 (1.2-11.9)<0.001
Early PHE expansion, (%)17 (11.8)39 (43.8)<0.001
SAH at baseline CT, (%)11 (7.6)9 (10.1)0.513
IVH at baseline CT, (%)28 (19.4)47 (52.8)<0.001
Hematoma growth, (%)27 (18.8)45 (50.6)<0.001
ICH location
 Basal ganglia hemorrhage, (%)95 (66.0)43 (48.3)0.008
 Thalamic hemorrhage, (%)29 (20.1)33 (37.1)0.004
 Other, (%)20 (13.9)13 (14.6)0.879
Outcome
In-hospital mortality, (%)0 (0)16 (18.0)<0.001
30-day mortality, (%)0 (0)33 (37.1)<0.001
90-day mRS, median (IQR)1 (0-2)6 (4.5-6)<0.001

ICH: intracerebral hemorrhage; CT: computed tomography; IVH: intraventricular hemorrhage; SAH: subarachnoid hemorrhage; GCS: Glasgow Coma Scale; mRS: modified Rankin scale; PHE: perihematomal edema; IQR: interquartile range; and SD: standard deviation.