I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice

Figure 2

IKKε deficiency attenuated the cardiac dysfunction after Ang II stimulation. (a) Representative images and quantitative analyses of western blot showing the expression of IKKε in the heart tissue of WT and IKKε-KO mice ( vs. WT). (b) Changes in blood pressure after Ang II infusion. (c) Representative images showing the echocardiography of WT and IKKε-KO mice that were infused with saline or Ang II for 8 weeks. (d) Analysis of echocardiography parameters (LVPWd, EF, FS, and E/A) of WT and IKKε-KO mice that were infused with saline or Ang II for 8 weeks ( mice per experimental group; vs. saline or WT Ang II).

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