I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice

Figure 4

IKKε knockout decreased the inflammatory reaction and fibrosis in Ang II-induced myocardial hypertrophy. Relative mRNA levels of heart failure markers (a) (atriopeptin, brain natriuretic peptide, Acta-1, and β-MHC), inflammatory factors (b) (IL-6, TNF-α, IL-1β, and IL-10), and fibrosis-related factors (c) (TGF-β1, CTGF, Collagen 1a1, and Collagen 3a1) in the heart tissues of WT or IKKε-KO mice after Ang II infusion ( mice per experimental group; vs. saline or WT Ang II).

(a)

(b)

(c)