I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice

Figure 7

The lack of IKKε reduced pyroptosis in myocardial tissue after Ang II infusion. (a, b) Representative IHC images and analyses of IL-1β and IL-18 in WT and IKKε-KO mouse heart tissue after 8 weeks of Ang II infusion ( mice per experimental group, 400x, vs. saline or WT Ang II). (c) Representative western blots and quantitative analyses of pyroptosis-related proteins in the heart tissue of WT and IKKε-KO mice that were infused with Ang II for 8 weeks ( mice per experimental group, vs. saline or WT Ang II).

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