I-κB Kinase-ε Deficiency Attenuates the Development of Angiotensin II-Induced Myocardial Hypertrophy in Mice

Figure 8

IKKε deficiency inhibits the Ang II-mediated MEK1/2-ERK1/2 and P38 signaling pathways. (a, b) Representative western blots showing the phosphorylation and total protein levels of the MAPK pathway proteins MEK1/2, ERK1/2, JNK, and p38 and the NF-κB pathway proteins IκBα, p65, RelB, and p100 in the heart tissue of WT and IKKε-KO mice that were infused with Ang II for 8 weeks ( independent experiments). (c) Relative quantitative analyses of western blot analysis of the MAPK pathway ( mice per experimental group; vs. saline or WT Ang II). (d) Relative quantitative analyses of western blot analysis of the NF-κB pathway ( mice per experimental group; ^# vs. saline).

(a)

(b)

(c)

(d)