Dot1l Aggravates Keratitis Induced by Herpes Simplex Virus Type 1 in Mice via p38 MAPK-Mediated Oxidative Stress

Figure 4

Dot1l expression was elevated induced by HSV-1 infection 3, 6, and 12 hours in HCE cells. Western blot was performed for the expression of Dot1l (a) after HSV-1 infection 3, 6, and 12 hours in HCE cells, and quantification of their expression (b) in fold change relative to the control group. SOD activity (c), MDA content (d), ROS (e), and H2O2 production (f) were also detected at HSV-1 infection 3, 6, and 12 hours in HCE cells. Data were expressed as (). versus control group; ^# versus HSV-1 3 h group. Experiments were repeated 3 times.

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