Effect of Methylene Blue on White Matter Injury after Ischemic Stroke

<div>TTC staining, infarction ratio of rat brain, percentage of foot fault, and Garcia neurofunctional scores in Experiment 1. (a) Representative samples of TTC-stained brain section at 24 h after MCAO. No ischemic lesion was found in the Sham group. Severe infarction was shown in MCAO mice. The white areas represented the infarct regions in these sections. MB reduced the infarction volume. (b) Statistical analysis of the infarction ratio, which was calculated as follows: the infarcted volume of the ipsilateral hemisphere divided by the total contralateral hemisphere. The statistical analysis showed that MB significantly reduced the infarction volume. (c) Percentage of foot fault. MB significantly reduced the percentage of foot fault. (d) Grades of 3-18 were used for Garcia neurofunctional scores. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Effect of Methylene Blue on White Matter Injury after Ischemic Stroke 