α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells

Figure 2

LA can induce mitochondrial ROS level of lung cancer cells. (a) The cells were incubated with 1.5 mM LA for 24 h and 48 h, and the mitochondria ROS was measured using MitoSOX red probe. (b) After incubation with 1.5 mM LA for 24 h and 48 h, the apoptotic proteins Bcl-2 and caspase-9 were examined by western blotting. (c) NAC quenched the ROS induced by LA. (d) NAC abbreviated the apoptotic effect induced by LA. Results are shown as the indicates ; indicates .

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