<i>α</i>-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells

<div>Downregulation of NRF2 by LA-induced apoptosis of A549 and PC9 cells. (a) NRF2 protein was downregulated in a dose- and time-dependent manner. (b) NRF2 and caspase-9 were examined in NRF2 expression plasmid transfected cells by western blotting. (c) Mitochondria ROS was measured by the MitoSOX red probe upon cells transfected with NRF2 expression plasmid after LA exposure. (d) NRF2 overexpression attenuated the LA-induced apoptosis in A549 and PC9 cells. (e) siRNA of NRF2-induced mitochondrial ROS and apoptosis. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: <i>α</i>-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells 

Oxidative Medicine and Cellular Longevity

α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells

Figure 3