α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells

Figure 6

Schematic illustration of the apoptotic effect of LA in human lung cancer cells. LA inhibits PDK1, releasing Keap1 binded by p-PDH. NRF2 is then recaptured by Keap1 for degradation, initiating the ROS-induced apoptosis.