Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis

Figure 1

Effect of HSYA on HR-induced myocardial injury in NPCMs. NPCMs were preincubated with HSYA (2.5, 5, and 10 μM) and nisoldipine (100 nM) for 24 h, followed by hypoxia (6 h) and reoxygenation (24 h). (a) Cell viability was detected using the CCK-8 assay. (b–d) Myocardial injury was assessed by detecting lactic dehydrogenase (LDH), aspartate transaminase (AST), and creatine kinase-MB (CK-MB) levels in NPCMs. Data are expressed as the . ^### vs. control group; vs. HR group, vs. HR group, and vs. HR group.

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