Radiation Can Regulate the Expression of miRNAs Associated with Osteogenesis and Oxidation in Exosomes from Peripheral Blood Plasma

Table 4

Target genes for irradiation-responsive miRNAs and detailed information about their target genes.

miRNA name	Target gene	Location	Biological process
hsa-miR-30a-5p	POLR3E	Chromosome 16: 22,297,375-22,335,103 forward strand	RNA polymerase III activity
hsa-miR-186-5p	MAP3K2	Chromosome 2: 127,298,730-127,388,465 reverse strand	MAPK cascade
hsa-miR-28-3p	TMEM167B	Chromosome 1: 109,089,803-109,096,934 forward strand	Protein secretion, intracellular transport
hsa-miR-130b-3p	AGO2	Chromosome 8: 140,520,156-140,635,619 reverse strand	Wnt signaling pathway, calcium modulating pathway, miRNA metabolic process
hsa-miR-16-2-3p	RORA	Chromosome 15: 60,488,284-61,229,319 reverse strand	Angiogenesis, negative regulation of fat cell differentiation
hsa-miR-142-3p	MAP4K3	Chromosome 2: 39,249,266-39,437,312 reverse strand	MAPK cascade, response to UV
hsa-miR-223-5p	FGF7	Chromosome 15: 49,423,096-49,488,775 forward strand	Mesenchymal cell proliferation, MAPK cascade, positive regulation of cell proliferation
hsa-miR-4454	CRCP	Chromosome 7: 66,114,604-66,154,568 forward strand	Neuropeptide signaling pathway
ocu-miR-191-5p	CASK	Chromosome X: 41,514,934-41,923,463 reverse strand	Positive regulation of calcium ion import
hsa-miR-145-5p	ROCK1	Chromosome 18: 20,946,906-21,111,851 reverse strand	Rho protein signal transduction, I-kappaB kinase/NF-kappaB signaling
hsa-let-7d-5p	HMGA2	Chromosome 1: 36,339,624-36,385,896 reverse strand	Regulation of MAPK cascade
oan-let-7b-3p ssc-mir-1285	The genes from Ornithorhynchus anatinus and Sus scrofa are still unknown.

Target genes for irradiation-responsive miRNAs and detailed information about their target genes, including gene location and functional annotation were shown, while two novel miRNAs are not included in this table. They were selected as significantly uploaded () miRNAs, especially clustering in osteogenesis.