Hydrogen: Potential Applications in Solid Organ Transplantation

Table 1

Application of hydrogen in different organs.

Organ	Use-pattern	Time	Reference
Lung	2–3% hydrogen	Donor	[35–38, 41]
Lung	Hydrogen-rich solution	Cold ischemia phase	[39, 40, 48]
Lung	2% hydrogen	EVLP	[43, 45, 46]
Lung	3% hydrogen	PMVECs	[42]
Lung	3% hydrogen & CO	Cold ischemia phase	[46]
Lung	2% hydrogen	During lung transplantation	[47]
Liver	Hydrogen-rich solution	Cold ischemia phase	[48, 50]
Liver	Hydrogen flush after cold storage	Cold ischemia phase	[49]
Liver	Hydrogen-rich perfusion fluid	Cold ischemia phase	[51]
Kidney	Hydrogen-rich solution	Cold ischemia phase	[52, 53]
Small intestine	Hydrogen-rich solution	Cold ischemia phase	[54, 55]
Small intestine	Hydrogen-bubbled preservation solution	Cold ischemia phase	[56]
Small intestine	2% hydrogen	Perioperative period	[57]
Heart	1–3% hydrogen	1 h before and after reperfusion	[58]
Heart	Hydrogen-rich water bath	Cold ischemia phase	[59]
Heart	Hydrogen-rich solution	Cold ischemia phase	[60]