Nlrp3 Deficiency Alleviates Angiotensin II-Induced Cardiomyopathy by Inhibiting Mitochondrial Dysfunction

Figure 1

Nlrp3 deletion attenuated Ang II-induced cardiac fibrosis. Representative photomicrographs of Masson’s trichrome-stained heart sections ((a) magnification ×400); the area of cardiac fibrosis (%) was evaluated as described in the Materials and Methods section (b). Semiquantitative analysis of heart fibronectin (c) and collagen I (d). mRNA expression was normalized to GAPDH and measured using real-time PCR. All values are (). versus the WT/vehicle control group; versus the WT/Ang II group. FN: fibronectin; Col I: collagen I.

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