Nlrp3 Deficiency Alleviates Angiotensin II-Induced Cardiomyopathy by Inhibiting Mitochondrial Dysfunction

Figure 6

NLRP3 deletion ameliorates Ang II-induced mitochondrial dysfunction in the heart. (a) The protein expression of heart PGC1a and TFAM in the heart were measured by Western blotting and (b) the levels were normalized to β-actin in mice in the four groups. (c) Semiquantitative analysis of mitochondrial DNA (mtDNA) levels and (d) ATP synthase levels in mice from the four groups normalized to 18S and performed by real-time PCR. All values are the (). versus the WT/vehicle control group; versus the WT/Ang II group.

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