Preclinical Evaluation of Safety, Pharmacokinetics, Efficacy, and Mechanism of Radioprotective Agent HL-003

<div>HL-003 suppressed the expression of apoptosis-related proteins p53, caspase-8, and caspase-9 in the small intestine of irradiated mice. (a) Representative immunofluorescence images for the expression of p53, caspase-8, and caspase-9 in tissue samples of the small intestine (green: p53, caspase-9, and -8). (b) Quantitative histogram analysis of p53 positive signal. (c) Quantitative histogram analysis of caspase-9 positive signal. (d) Quantitative histogram analysis of caspase-8 positive signal. 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Oxidative Medicine and Cellular Longevity

fig10

Figure 10

Figure 10: Preclinical Evaluation of Safety, Pharmacokinetics, Efficacy, and Mechanism of Radioprotective Agent HL-003 