Research Article
Preclinical Evaluation of Safety, Pharmacokinetics, Efficacy, and Mechanism of Radioprotective Agent HL-003
Figure 2
Oral administration of different HL-003 doses improved the survival rate in irradiated mice, whereas oral amifostine had no beneficial effect. Male C57BL/6 mice received oral HL-003 or amifostine 1 or 0.5 h before WAI. Kaplan-Meier survival analysis of mice exposed to 8.0 Gy (, ; group size, or ).