Research Article

Preclinical Evaluation of Safety, Pharmacokinetics, Efficacy, and Mechanism of Radioprotective Agent HL-003

Figure 3

The optimal administration time of oral HL-003 was 4 h before irradiation. The 30-day survival rate of each group was evaluated after oral administration of 1600 mg/kg HL-003 at 0.5, 1, 2, and 4 h before irradiation. Kaplan-Meier survival analysis of mice exposed to 8.0 Gy (; group size, ).