Preclinical Evaluation of Safety, Pharmacokinetics, Efficacy, and Mechanism of Radioprotective Agent HL-003

Table 1

Acute toxicity test of HL-003 and amifostine in C57BL/6 mice.

mg/kg	Survival rate
	600	700	800	1200	1600	1800	2000	2400	3200
Amifostine	100% (6/6)	83.33% (5/6)	66.67% (4/6)	NA	NA	NA	NA	NA	NA
HL-003	NA	NA	NA	100% (10/10)	100% (10/10)	100% (10/10)	50% (5/10)	40% (4/10)	0% (0/10)

NA: not available. NA indicates that no acute toxicity test was conducted at this dose. (): represents the number of surviving mice 14 days postadministration and represents the number of mice in each group preadministration.