Preclinical Evaluation of Safety, Pharmacokinetics, Efficacy, and Mechanism of Radioprotective Agent HL-003
Table 3
PK parameters of HL-003 in SD rats. SD rats (group size, ) received an HL-003 dose of 100 mg/kg i.v. or 400 mg/kg p.o., and blood samples were collected from 0 to 24 h for PK parameter analysis.
PK parameter
Mean
Standard deviation
PK parameters of HL-003 in male SD rats after a dose of 100 mg/kg i.v.
HL_Lambda_z (, h)
0.67
0.28
(ng/mL)
77510.6
2202.1
AUClast (hng/mL)
30589.1
1199.2
AUCINF_pred (hng/mL)
30606.8
1198.3
MRTlast (h)
0.32
0.05
Vz_pred (L/kg)
3.15
1.26
Cl_pred (L/h/kg)
3.27
0.13
Λz calculation time range (h)
NA
NA
PK parameters of HL-003 in male SD rats after a dose of 400 mg/kg p.o.
HL_Lambda_z (, h)
6.65
2.49
(h)
0.28
0.21
(ng/mL)
21580.4
8971.2
AUClast (hng/mL)
51744.1
8389.0
AUCINF_pred (hng/mL)
55842.4
6086.6
MRTlast (h)
5.71
0.70
Vz_F_pred (L/kg)
70.55
32.64
Cl_F_pred (L/hr/kg)
7.22
0.82
λz calculation time range (h)
NA
NA
(%)
42.29
6.86
NA: not available. NA means that the data has not been calculated.
