Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway

Figure 3

TP alleviated the degeneration of nucleus pulposus cells caused by H₂O₂ in a dose-dependent manner. After the treatment of TP, (a) the proliferation rate of cells came back to normal. The relative mRNA expression of (b) collagen II, (c) aggrecan, and (d) Sox-9 increased significantly, while that of (e) collagen X and (f) MMP-3 decreased significantly. (g, h) And the relative protein level of collagen II increased significantly ().

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)