Zi Shen Decoction Inhibits Growth and Metastasis of Lung Cancer via Regulating the AKT/GSK-3β/β-Catenin Pathway

Figure 6

ZSD inhibited the AKT/GSK-3β/β-catenin pathway in lung cancer cells and tumor tissues. (a) Western blot analysis was used to assess the expression of multiple proteins involved in the AKT/GSK-3β/β-catenin pathway in lung cancer cells after ZSD treatment for 12 h, 24 h, and 48 h. , , and vs. the control group. (b) Western blots showing the protein expression of AKT, p-AKT, GSK-3β, p-GSK-3β, β-catenin, cleaved caspase-3, and Bax and Bcl-2 in isolated tumor tissues. , , and vs. the model group.

(a)

(b)