General Control of Amino Acid Synthesis 5-Like 1-Mediated Acetylation of Manganese Superoxide Dismutase Regulates Oxidative Stress in Diabetic Kidney Disease

Figure 1

The expression of GCN5L1 is significantly elevated in kidney tissues from diabetic kidney disease patients and mouse models. (a) Immunohistochemistry staining for GCN5L1 expression in human renal biopsies. . (b) Urine albumin-to-creatine ratio (UACR) in STZ-induced diabetic mice. Independent experiments were performed in triplicate. (c) Hematoxylin and eosin staining, Masson’s trichrome staining, and periodic acid-Schiff staining in the kidneys from STZ-induced diabetic mice. . (d) Immunohistochemistry staining for GCN5L1 expression in mouse kidney tissues. . (e, f) Western blotting analysis of GCN5L1 protein expression in the kidneys from STZ-induced diabetic mice. Data are presented as the . ; .

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