Research Article
An Oxidative Stress Index-Based Score for Prognostic Prediction in Colorectal Cancer Patients Undergoing Surgery
Table 1
Clinicopathological characteristics of all patients.
| | Characteristics | Test set (n=1022), % | Validation set (n=400), % | P |
| | Age (years) | | | 0.557 | | ≥60 | 478 (46.8) | 194 (48.5) | | | <60 | 544 (53.2) | 206 (51.5) | | | Sex, male | 590 (57.7) | 235 (58.8) | 0.726 | | Primary site | | | 0.587 | | Left colon | 310 (30.3) | 124 (31.0) | | | Right colon | 197 (19.3) | 83 (20.8) | | | Rectum | 515 (50.4) | 193 (48.3) | | | Family history of cancer | 99 (9.7) | 47 (11.8) | 0.557 | | Histological grade | | | 0.567 | | Well differentiated | 153 (15.0) | 60 (15.0) | | | Moderately differentiated | 800 (78.3) | 319 (79.8) | | | Poorly differentiated | 69 (6.7) | 21 (5.2) | | | Tumor size | | | 0.144 | | <2 cm | 51 (5.0) | 25 (6.2) | | | 2-5 cm | 597 (58.4) | 243 (60.8) | | | ≥5 cm | 374 (36.6) | 132 (33.0) | | | Lymphovascular invasion | | | 0.364 | | Yes | 187 (18.3) | 65 (16.3) | | | No | 835 (81.7) | 335 (83.7) | | | Circumferential resection margin | | | 0.576 | | Yes | 11 (1.1) | 3 (0.8) | | | No | 1011 (98.9) | 397 (99.2) | | | T stage | | | 0.505 | | T1 | 73 (7.1) | 33 (8.3) | | | T2 | 169 (16.5) | 64 (16.0) | | | T3 | 539 (52.7) | 215 (53.7) | | | T4 | 241 (23.7) | 88 (22.0) | | | N stage | | | 0.065 | | N0 | 59 (5.8) | 15 (3.8) | | | N1 | 539 (52.7) | 198 (49.5) | | | N2 | 251 (24.6) | 112 (28.0) | | | N3 | 173 (16.9) | 75 (18.7) | | | TNM stage | | | 0.563 | | Stage I | 140 (13.7) | 53 (13.2) | | | Stage II | 352 (34.4) | 130 (32.5) | | | Stage III | 394 (38.6) | 163 (40.8) | | | Stage IV | 136 (13.3) | 54 (13.5) | | | Adjuvant chemotherapy | | | 0.529 | | Yes | 492 (48.1) | 200 (50.0) | | | No | 530 (51.9) | 200 (50.0) | | | Radiotherapy | | | 0.499 | | Yes | 55 (5.4) | 18 (4.5) | | | No | 967 (94.6) | 382 (95.5) | | | Serum albumin | | | 0.176 | | ≥36.3 g/L | 794 (77.7) | 318 (79.5) | | | <36.3 g/L | 228 (22.3) | 82 (20.5) | | | Total bilirubin | | | 0.431 | | ≥12.2 μmol/L | 389 (38.1) | 159 (39.8) | | | <12.2 μmol/L | 633 (61.9) | 241 (60.2) | | | Direct bilirubin | | | 0.732 | | ≥5.2 μmol/L | 227 (22.2) | 105 (26.3) | | | <5.2 μmol/L | 795 (77.8) | 295 (73.7) | | | Urea nitrogen | | | 0.144 | | ≥4.6 mmol/L | 616 (60.3) | 233 (58.2) | | | <4.6 mmol/L | 406 (39.7) | 167 (41.8) | | | Uric acid | | | 0.081 | | ≥200.0 μmol/L | 888 (86.9) | 361 (90.3) | | | <200.0 μmol/L | 134 (13.1) | 39 (9.8) | | | Overall survival months | 29.5 (21.8, 40.1) | 29.6 (22.3, 40.7) | 0.198 | | Disease-free survival months | 20.0 (12.7, 30.2) | 20.2 (13.1, 30.3) | 0.732 | | Death, n (%) | 174 (17.0) | 59 (14.8) | 0.298 | | Recurrence, n (%) | 152 (14.9) | 60 (15.0) | 0.952 |
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